Three single-vehicle crashes occurred Wednesday on Interstate 10 between Avra Valley and Tangerine roads.
In two crashes, the vehicles' occupants refused medical attention, said Capt. Brian Keeley of Northwest Fire District.
One person was treated by paramedics and taken to a hospital with non-life threatening injuries in the third crash, said Keeley.
Westbound I-10 has one lane closed, and the eastbound lanes are open, said Keeley.
Arizona Department of Public Safety troopers were investigating the crashes.
No further information was immediately available.