Nancy Guthrie is "still out there" and investigators are operating from an assumption that the mother of NBC "Today" show host Savannah Guthrie is still alive, Pima County Sheriff Chris Nanos said at a news conference Thursday.
DNA tests showed blood found on Guthrie's porch was hers.
More "items" have been submitted as evidence, Nanos said, but he did not go into detail.
He also wouldn't say if blood was found elsewhere at Guthrie's Catalina Foothills home.
Nanos reiterated that there are no specific suspects or persons of interest identified in the investigation. He also noted that no one has been ruled out.
"We're actively looking at everybody we come across in this case. Everybody," Nanos said. "Everybody's still a suspect in our eyes."
Sheriff Chris Nanos speaks during a news conference Thursday regarding the disappearance of Nancy Guthrie, the 84-year-old mother of NBC "Today" show host Savannah Guthrie.
More detailed timeline
Investigators on Thursday shared a more precise timeline showing that Guthrie, 84, was taken from her home in the early hours of Sunday, Feb. 1.
Guthrie took an Uber ride at 5:32 p.m. Saturday to go to a family member's home for dinner. A family member brought her back home at 9:48 p.m. Her home's garage door was closed at 9:50 p.m.
At 1:47 a.m. the home's doorbell camera was disconnected. Nanos said that doorbell camera is not in the department's possession.
At 2:12 a.m., "software detects a person on a camera," but no video is available because Guthrie did not have a subscription to the surveillance service, Nanos said.
At 2:28 a.m., Guthrie's pacemaker disconnected from her cellphone, he said.
Guthrie's family checked on Nancy at 11:56 a.m. after learning from her church that she did not attend services.
At 12:03 p.m. Sunday, the family called 9-1-1 to report her missing. Deputies arrived at 12:15, Nanos said.
Investigators have searched cameras from nearby neighbors and businesses, while deputies checked with local hospitals hourly following Guthrie's disappearance, Nanos said.
Authorities know what medication Guthrie needs, Nanos said, which he has stressed repeatedly throughout the week. Without it, Nanos has said, Guthrie's survival is in peril. Given the dire need for her medication, Nanos said investigators contacted local pharmacies early on in their search, and will probably do so again.
Heith Janke, special agent in charge, FBI, on Thursday said agents from Tucson and its Phoenix office are helping investigate the disappearance of Nancy Guthrie.
Search area expands across region
The FBI is now working jointly with Pima County including bringing in "agents, analysts and professional staff."
Heith Janke, FBI special agent in charge from Phoenix, also announced a $50,000 reward for any information that can lead to the recovery of Guthrie or an arrest.
Janke said FBI resources have grown considerably.
"The FBI has agents, analysts and professional staff, employees working day and night with our partners at the Sheriff's Department," he said. "We have deployed additional intelligence and agents from our Phoenix office, we have brought in our critical incident response group from Quantico, Virginia, members from our cellular analysis survey team are here, and they continue to collect and process digital information."
Crisis negotiators from the FBI's local team as well as from Quantico have been brought in, Janke said.
FBI Director Kash Patel has been briefed "several times a day" on the investigation and will be coming to Tucson, Janke said. He gave no information on when Patel will be here.
An updated timeline was released by the Pima County Sheriff’s Department Thursday in the disappearance of Nancy Guthrie.
"(Patel) does have a trip scheduled to Tucson, that was pre-scheduled before this, but he is receiving consistent and constant updates from our team here," he said, encouraging anyone with information, "no matter how small you think it may be," to report it to the agency by calling 1-800-CALL-FBI or online at www.tips.fbi.gov.
The search for Guthrie has already expanded across the state, but the FBI will be extending it to neighboring states, Nanos said, and billboards "are going to be out there across the country."
Additionally, the Pima Regional Critical Incident Team, the multi-agency group that normally investigates local shootings in which officers are involved, has been activated.
Nanos said he hasn't been in contact with authorities in Mexico. Janke said investigators will follow the facts but noted, "We have no indication of anything over the Mexican border."
Nancy Guthrie
Ransom note gave deadlines
A ransom note received by some media organizations is being taken seriously, Nanos and Janke said. It includes facts associated with the case that are not widely known. Separately, a ransom demand sent to two family members resulted in the arrest of a California man.
The ransom letters being investigated gave two deadlines for payment: The first at 5 p.m. Thursday, a second on Monday, Feb. 9, Janke said.
But neither Nanos nor Janke provided details in terms of what the ransom note says will happen if those deadlines are not met.
No instructions for communication were provided, nor has there been contact after that ransom note was received and shared with law enforcement, Janke said.
In a new video Thursday evening, Camron Guthrie told "whoever is out there holding our mother" that the family wants to hear from them "but first, we have to know that you have our mom."
"We want to hear from you. We haven't heard anything directly. We need you to reach out," Camron Guthrie said in the video on Instagram, saying he is speaking for the family.
"We need a way to communicate with you so we can move forward," he adds. "We want to talk to reach and we are waiting for contact."
The video apparently was posted online about the time or after the 5 p.m. Thursday deadline for payment in the purported ransom note.
FBI assists in family's plea
In an emotional video released Wednesday, Savannah Guthrie, flanked by her siblings Camron and Annie, pleaded with her mother's abductor to return the 84-year-old to her Tucson home and reunite her with her family.
The FBI assisted in making that video, Janke said Thursday.
Media members saw FBI agents Wednesday night carrying a tripod into the home of Savannah's sister. Janke said the agency uses their expertise in these cases to "provide consultation and advice."
"Anytime a family would ask for our advice in a kidnapping, it's ultimately the family's decision of what they put out, and any messages they put out," Janke said Thursday. "We were there last night and talking with the family ... we have an expertise when it comes to kidnapping and when families want advice, consultation, expertise, we will provide that."
Guthrie's family is ready to talk, Janke said, speaking before Camron Guthrie's video was released, because no contact has been made after the ransom note was received.
"If those that may have Nancy are watching this, the family is ready to talk," Janke said, Thursday staring directly in cameras of the many media organizations from around the globe at Thursday's news conference.
"Give proof of life, because there has been no contact after that ransom note went to media."
Hundreds of Tucsonans gathered Wednesday night for a candlelight service to offer their support for the Guthrie family.
