CAPE CANAVERAL, Fla. β€” Four astronauts embarked on a high-stakes flight around the moon Wednesday, humanity's first lunar voyage in more than half a century and the thrilling leadoff in NASA's push toward a landing in two years.

Carrying three Americans and one Canadian, the 32-story rocket rose from NASA's Kennedy Space Center where tens of thousands gathered to witness the dawn of this new era. Crowds also jammed the surrounding roads and beaches, reminiscent of the Apollo moonshots in the 1960s and '70s. It is NASA's biggest step yet toward establishing a permanent lunar presence.

Artemis II set sail from the same Florida launch site that sent Apollo's explorers to the moon. The handful still alive cheered this next generation's grand adventure as the Space Launch System rocket thundered into the early evening sky, a nearly full moon beckoning about 248,000 miles away.

Astronauts, from left, Mission Specialist Jeremy Hansen of Canada, Pilot Victor Glover, Commander Reid Wiseman and Mission Specialist Christina Koch leave the Operations and Checkout Building onΒ Wednesday for a trip to Launch Pad 39-B and a planned liftoff on NASA's Artemis II moon rocket at the Kennedy Space Center in Cape Canaveral, Fla.

Artemis II commander Reid Wiseman led the charge into space with "Let's go to the moon!" accompanied by pilot Victor Glover, Christina Koch and Canada's Jeremy Hansen. It was the most diverse lunar crew ever with the first woman, person of color and non-U.S. citizen riding in NASA's new Orion capsule.

They shaped their hands into hearts as they said goodbye to their families and boarded the astrovan for the ride to the pad and their awaiting space chariot. "Love you guys," Glover said.

The astronauts will stick close to home for the first 25 hours of their 10-day test flight, checking out the capsule in orbit around Earth before firing the main engine that will propel them to the moon.

They won't pause for a stopover or orbit the moon like Apollo 8's first lunar visitors did so famously on Christmas Eve 1968, reading from Genesis. But they stand to become the most distant humans ever when their capsule zooms past the moon and continues another 4,000 miles beyond, before making a U-turn and tearing straight home to a splashdown in the Pacific.

NASA's Artemis II moon rocket lifts off Wednesday from the Kennedy Space Center's Launch Pad39-B in Cape Canaveral, Fla.

Once settled in a high orbit around Earth, the astronauts planned to assume manual control and practice steering their capsule around the rocket's detached upper stage, venturing within 33 feet. NASA wants to know how Orion handles in case the self-flying feature fails and the pilots need to take control.

Four days later during the lunar flyby, the moon will appear to be the size of a basketball held at arm's length. The astronauts will take turns peering through Orion's windows with cameras. If the lighting is right, they should see features never before viewed through human eyes. They'll also catch snippets of a total solar eclipse, donning eclipse glasses as the moon briefly blocks the sun from their perspective and the corona is revealed.

All of NASA's moon plans β€” a surge in launches over the next several years leading to a sustainable moon base for astronauts assisted by robotic rovers and drones β€” hinge on Artemis II going well.

It's been more than three years since Artemis I, the only other time NASA's SLS rocket and Orion capsule soared. With no one aboard, the Artemis I capsule lacked life-support equipment and other crew essentials like a water dispenser and toilet.

These systems are now making their space debut on Artemis II, ratcheting up the risk.

NASA employees react Wednesday as astronauts leave the Operations and Checkout Building for a trip to Launch Pad 39-B and a planned liftoff on NASA's Artemis II moon rocket at the Kennedy Space Center in Cape Canaveral, Fla.

"There's always been a lot riding on this mission," NASA's Lori Glaze said ahead of launch. But the teams are even more "energized" now that the space agency is finally accelerating the lunar launch pace and laser-focusing on surface operations β€” seismic changes announced recently by new administrator Jared Isaacman.

Until Isaacman's program makeover, Artemis III was crawling toward a moon landing no sooner than 2029. The billionaire spacewalker slid in a new Artemis III for 2027 so astronauts could practice docking their Orion capsule with a lunar lander in orbit around Earth. Astronauts' momentous landing near the moon's south pole shifted to Artemis IV in 2028 β€” two years before an anticipated Chinese crew's arrival.

Like Apollo 13 β€” astronauts' only moon landing miss β€” Artemis II will use a free-return, lunar flyby trajectory to get home with gravity's tug and a minimum of gas. The gravity of both the moon and Earth will provide much if not most of the oomph to keep Orion on its out-and-back, figure-eight loop.

Speaking with FRANCE 24's Sharon Gaffney, Dr David Brown, Senior Research Fellow in the Astronomy and Astrophysics Group at Warwick University, hopes that the Artemis II mission "is the start of a new era of human spaceflight", adding that "it is incredibly exciting and inspiring to see that this is still something that wa can do and something that people can aspire to do".

The danger is right up there for Artemis II. NASA refused to release its risk assessment for the mission. Managers contend it's better than 50-50 β€” the usual odds for a new rocket β€” but how much more is murky.

The SLS rocket leaked flammable hydrogen fuel during ground tests, a recurring problem that engineers still do not completely understand. The hydrogen leaks and unrelated helium blockages stalled the flight for two months, coming on top of years of vexing delays and cost overruns. Both problems also thwarted Artemis I, whose capsule returned with excessive heat shield damage.

To NASA's relief, Wednesday's countdown was leak-free but a few issues cropped up in the final hours.

"It is our strong hope that this mission is the start of an era where everyone, every person on Earth, can look at the moon and think of it as also a destination," Koch said at a weekend news conference.

"It's the story of humanity," Glover added. "Not Black history, not women's history, but that it becomes human history."


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