Construction crews will close the right lane of eastbound Interstate 10 between Cortaro and Ina roads beginning at 10 p.m.
The road striping work will last until 5 a.m. Friday, according to the Arizona Department of Transportation.
"The ongoing Ina Road work requires lane closures and traffic shifts through April 15, between Silverbell Road and Camino de las Capas," an ADOT news release said.
Motorists should use caution and watch for personnel in the area.