The NFL Week 16 slate begins on Thursday, Dec. 21 and concludes on Christmas Day with a marquee Monday Night Football inter-conference holiday showdown between the 49ers and Ravens.
Below are early Week 16 NFL odds for all games plus betting previews for the biggest games on the schedule.
2023 NFL Week 16 odds: Spread, moneyline favorite on every Week 16 NFL game
Week 16 Early NFL odds: New Orleans at Los Angeles Rams (-4, -200) - Thursday, 8:15 p.m. ET
The Saints and Rams moved to 7-7 with their Week 15 wins, and New Orleans also has a path into the postseason through an NFC South crown.
The Saints will hope to have Chris Olave back from his ankle injury for this matchup, but the red-hot Matthew Stafford and his talented supporting cast figure to present quite the challenge.
NFL betting lines Week 16: Cleveland Browns at Houston Texans (-2.5, -141) - Sunday, 1:00 p.m. ET
Two surprising AFC squads face off in a matchup that may ultimately decide the postseason fate of at least one of them. Cleveland pushed its record to a surprising 9-5 with another close win versus the Bears in Week 15.
The Texans were just as impressive in pulling out an overtime win over the Titans without C.J. Stroud, who oddsmakers seem to be anticipating will be available based on this opening line.
NFL odds next week: Dallas at Miami (-1.5, -130) - Sunday, 4:25 p.m. ET
The Cowboys finally upended a quality opponent in Week 15 and promptly took a 31-10 throttling from the Bills on Sunday.
The Dolphins trampled the Jets without Tyreek Hill (ankle), who could ultimately be a game-time decision for this marquee matchup.
Baltimore at San Francisco (-5.5, -210) - Monday, 8:15 p.m. ET
The Ravens headed into their Week 15 Sunday night matchup against the Jaguars with a 10-3 record and needing a win to stay a game ahead of the Dolphins for the AFC’s top seed.
The Niners rolled to their sixth straight win and an 11-3 mark with Sunday’s win over the Cardinals, but could head into Week 16 tied with the Eagles for the conference’s top mark.
Early NFL Odds Week 16
- Cincinnati (-2.5) at Pittsburgh - 4:30 p.m. ET, Saturday, 12/23
- Buffalo (-14) at Los Angeles Chargers - 8 p.m. ET, Saturday, 12/23
- Detroit (-3.5) at Minnesota -1 p.m. ET
- Seattle (-2.5) at Tennessee - 1 p.m. ET
- Indianapolis at Atlanta (-2) - 1 p.m. ET
- Washington at New York Jets (-3.5) - 1 p.m. ET
- Green Bay (-5.5) at Carolina - 1 p.m. ET
- Jacksonville (-2.5) at Tampa Bay - 4:05 p.m. ET
- Arizona at Chicago (-4.5) - 4:25 p.m. ET
- New England at Denver (-5.5) - 8:15 p.m. ET
- Las Vegas at Kansas City (-10) - 1:00 p.m. ET, Monday, 12/25
- New York Giants at Philadelphia (-10.5) - 4:30 p.m. ET, Monday, 12/25
Best NFL Sportsbook Apps
Check out the list below featuring the best NFL betting apps in your state:
You must be over 21 to play. Gambling Problem? Call 1-800-522-4700. 1-800 GAMBLER.
