Big 12 Conference play is here in all its glory.
No more randoms non-con games at East Carolina or Oregon State.
Week 6 brings seven big-time Big 12 matchups, including two ranked teams (Iowa State, Texas Tech) hitting the road.
Our staff prognosticators, Michael Lev and Justin Spears, are back to pick every game on this week's slate straight up and against the spread. Lev and Spears are joined this season by Jordan Hamm of Sports360AZ.com.
For more on our predictions — plus an in-depth breakdown of the Arizona-Oklahoma State matchup — check out The Wildcast podcast. It’s available on Apple, Spotify or wherever you get your podcasts.
FRIDAY, Oct. 3
Matchup: West Virginia (+19.5) at No. 23 BYU
Time/TV: 7:30 p.m., ESPN
Hamm's prediction: BYU to win and cover
Lev’s prediction: BYU to win and cover
Spears’ prediction: BYU to win and cover
Baylor quarterback Sawyer Robertson warms up before facing Arizona State on Sept. 20, 2025, in Waco, Texas. (AP Photo/Jerry Larson)
SATURDAY, Oct. 4
Matchup: Kansas State (+6.5) at Baylor
Time/TV: 9 a.m., ESPN+
Hamm's prediction: Baylor to win and cover
Lev’s prediction: Kansas State to win outright
Spears’ prediction: Baylor to win and cover
Matchup: No. 14 Iowa State (+1.5) at Cincinnati
Time/TV: 9 a.m., ESPN2
Hamm's prediction: Cincinnati to win and cover
Lev’s prediction: Cincinnati to win and cover
Spears’ prediction: Cincinnati to win and cover
Iowa State wide receiver Carson Brown (10) tries to catch a pass as he is defended by Arizona defensive backs Treydan Stukes (2) and Michael Dansby (25) during their game on Sept. 27, 2025, in Ames, Iowa.
Matchup: Oklahoma State (+20.5) at Arizona
Time/TV: Noon, TNT
Hamm's prediction: Arizona to win, Oklahoma State to cover
Lev’s prediction: Arizona to win, Oklahoma State to cover
Spears’ prediction: Arizona to win and cover
Matchup: No. 11 Texas Tech (-11.5) at Houston
Time/TV: 4 p.m., ESPN
Hamm's prediction: Texas Tech to win and cover
Lev’s prediction: Texas Tech to win, Houston to cover
Spears’ prediction: Texas Tech to win, Houston to cover
TCU coach Sonny Dykes, left, and Colorado coach Deion Sanders shake hands after their game on Sept. 2, 2023, in Fort Worth, Texas.
Matchup: Colorado (+13.5) at TCU
Time/TV: 4:30 p.m., FOX/11
Hamm's prediction: TCU to win and cover
Lev’s prediction: TCU to win, Colorado to cover
Spears’ prediction: TCU to win and cover
Matchup: Kansas (-5.5) at UCF
Time/TV: 4:30 p.m., ESPN2
Hamm's prediction: Kansas to win and cover
Lev’s prediction: Kansas to win and cover
Spears’ prediction: Kansas to win and cover
LAST WEEK'S RECORDS
Hamm: 8-0 straight up, 4-4 against the spread
Lev: 7-1 SU, 5-3 ATS
Spears: 6-2 SU, 4-4 ATS
SEASON TO DATE
Hamm: 27-12 SU, 20-19 ATS
Lev: 26-13 SU, 20-19 ATS
Spears: 28-11 SU, 21-18 ATS
