You never know what will happen in the Big 12 Conference.
You might get rain in Tucson for a clash between 4-1 Arizona and 5-0 BYU.
You might get a quarterback injury that completely changes the outlook of a game.
We recorded the latest episode of The Wildcast podcast on Wednesday. The next day, Arizona State quarterback Sam Leavitt was downgraded from probable to doubtful. By Friday, he was ruled out for ASU's game at Utah.
The picks below courtesy of staff prognosticators Michael Lev and Justin Spears, plus 2025-26 guest picker Jordan Hamm of Sports360AZ.com, were made before that news broke. The spread for ASU-Utah subsequently has climbed from 5.5 to 9.5.
For more on our predictions — plus an in-depth breakdown of the Arizona-BYU matchup — check out The Wildcast. It’s available on Apple, Spotify or wherever you get your podcasts.
Oklahoma State cornerback Kenneth Harris (23) and linebacker Wendell Gregory (4) manage to break up the pass intended for Arizona wide receiver Chris Hunter (11) during the first quarter, Oct. 4, 2025, at Arizona Stadium.
SATURDAY, Oct. 11
Matchup: Houston (-14.5) at Oklahoma State
Time/TV: 9 a.m., TNT
Hamm's prediction: Houston to win and cover
Lev’s prediction: Houston to win, OSU to cover
Spears’ prediction: Houston to win and cover
Matchup: UCF (+11.5) at Cincinnati
Time/TV: 9 a.m., FS1
Hamm's prediction: Cincinnati to win, UCF to cover
Lev’s prediction: Cincinnati to win and cover
Spears’ prediction: Cincinnati to win, UCF to cover
Matchup: TCU (-1.5) at Kansas State
Time/TV: 12:30 p.m., FOX/11
Hamm's prediction: TCU to win and cover
Lev’s prediction: KSU to win outright
Spears’ prediction: KSU to win outright
Iowa State running back Abu Sama III (24) celebrates after scoring a touchdown against Arkansas State on Sept. 13, 2025, in Jonesboro, Ark.
Matchup: Iowa State (-2.5) at Colorado
Time/TV: 12:30 p.m., ESPN
Hamm's prediction: Iowa State to win and cover
Lev’s prediction: Iowa State to win and cover
Spears’ prediction: Iowa State to win and cover
Matchup: Kansas (+14.5) at Texas Tech
Time/TV: 4:30 p.m., FOX/11
Hamm's prediction: Kansas to win outright
Arizona wide receiver Tre Spivey (12) celebrates after ramming home a touchdown and losing his helmet in the process against Oklahoma State during the first quarter, Oct. 4, 2025, at Arizona Stadium.
Lev’s prediction: Texas Tech to win, Kansas to cover
Spears’ prediction: Texas Tech to win and cover
Matchup: BYU (-1.5) at Arizona
Time/TV: 5 p.m., ESPN2
Hamm's prediction: BYU to win and cover
Lev’s prediction: BYU to win and cover
Spears’ prediction: Arizona to win outright
Matchup: Arizona State (+5.5) at Utah
Time/TV: 7:15 p.m., ESPN
Hamm's prediction: Utah to win, ASU to cover
Lev’s prediction: Utah to win, ASU to cover
Spears’ prediction: ASU to win outright
LAST WEEK'S RECORDS
Hamm: 7-0 straight up, 4-3 against the spread
Lev: 6-1 SU, 3-4 ATS
Spears: 7-0 SU, 4-3 ATS
SEASON TO DATE
Hamm: 34-12 SU, 24-22 ATS
Lev: 32-14 SU, 23-23 ATS
Spears: 35-11 SU, 25-21 ATS
