University of Arizona vs Kansas State

Arizona running back Ismail Mahdi (21) hops his way out of trouble as he picks up yards after contact in the fourth quarter against Kansas State, Sept. 12, 2025, in Tucson.

Arizona is a three-score favorite in its Big 12 home opener against the struggling Oklahoma State Cowboys at Arizona Stadium on Saturday.Β Β 

The Wildcats are 19.5-point favorites to beat the Cowboys, according to Action Network.Β Arizona initially opened up as 16.5-point favorites.Β 

The over/under for Saturday afternoon is 54.5 points.Β 

Arizona's (3-1) matchup with Oklahoma State (1-3) will be the 10th all-time matchup between the two schools dating back to 1931. Arizona is 4-5 against the Cowboys, winning its last matchup, 59-38, in former head coach Rich Rodriguez's first season in 2012.

Before 2012, Arizona lost the previous two games to Oklahoma State, a 37-14 setback in Stillwater and a 36-10 beatdown in the Alamo Bowl to cap the 2010 season.

Since the start of last season, Oklahoma State is 4-12. The Cowboys recently lost to the Baylor Bears, the game after firing longtime head coach Mike Gundy. Offensive coordinator Doug Meacham is OSU's interim head coach.Β 

Oklahoma State fired defensive coordinator Todd Grantham on Sunday following the Cowboys' 45-27 loss to Baylor.Β 

Arizona and Oklahoma State kick off at Arizona Stadium Saturday at noon on TNT, TruTV and HBO Max.Β 


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Contact Justin Spears, the Star's Arizona football beat reporter, at jspears@tucson.com. On X(Twitter): @JustinESports