The eastbound lanes of Interstate 10 in Tucson are closed following a crash on Wednesday morning.
The crash happened at Craycroft Road, the Arizona Department of Transportation said.
According to Tucson Fire, the crash involved three tractor trailers and a van. Two people were pronounced dead at the scene and two others were taken to a local hospital.
Drivers should expect delays and are asked to seek an alternate route.
There is no estimated time of reopening.
Both directions of traffic on the I-10 near Kolb Road are also closed after a deadly crash caused a nitric acid spill on Tuesday.
Drivers can find real-time highway conditions at az511.gov, the state's traveler information website.
ADOT also posts updates on Twitter @ArizonaDOT.
Certain demographics are more likely to be pulled over than others, and the consequences for drivers who are subject to a traffic stop vary significantly.
