6. (tie) Tammy Baldwin and Claire McCaskill

Baldwin, a Wisconsin Senator, and McCaskill, a Missouri Senator, could both be intriguing national candidates -- albeit it from different ideological perspectives (Baldwin is more liberal, McCaskill more conservative.) The issue for both is that they face re-election races that could be problematic. McCaskill will be a major Republican target in a state that Trump won by 18 points in 2016. And Baldwin watched as Wisconsin re-elected Sen. Ron Johnson, R, in 2016 despite widespread expectations that former Sen. Russ Feingold, D, would win. Neither woman will be able to take their eyes off their re-election races, making it harder to plan for a 2020 bid.

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